DEP(Dermoelectroporation – alternative to injection)

DEP (DermoElectroPoration) System is the new Non Invasive, Standalone powered drug-delivery system carrying Dermoelectroporation® Technology to deliver Ionic drug solution into the body for medical purposes.


DEP (DermoElectroPoration) System is the new Non Invasive, Standalone powered drug-delivery system carrying Dermoelectroporation® Technology to deliver Ionic drug solution into the body for medical purposes.
As result of more than five years researches, Mattioli Dermoelectroporation®,

technology is consolidated to be an incredible procedure that allows the transdermal delivery of whatever substance operators want , which are otherwise not absorbed into the skin because of the typology and dimension of their own molecules.

Dermoelectroporation® infact, increases the skin’s permeability just using some skin’s water based channels opened by a particular controlled current delivered to the patient and allowing the substances to absobed till hypodermis and muscle membranes.

The system has been FDA approved for the “local administration of ionic drug solutions into the body for medical purposes and can be used as an alternative to injections“.

DEP System is made of the following devices:

§ Power supply and control base.

§ DEP Transdermal delivery handpiece with

Macromolecules (such as Hyaluronic Acid) previously not transdermally deliverable by traditional Ionthophoresis are now successfully deliverable due to the new Dermoelectroporation®Technology.

DEP System features:

•     Homogeneous drug delivered on the selected area.

•     Real time control on the amount of drug to delivered.

•     Real time patient’s skin impedance measurement for successful drug delivery.

•     Drug administration in a timely manner to avoid waste of product with 100% protection against external agents.

•     No Electrolysis effect – No drug PH modification

•     No need of Pre-charged compounds/ Carrying Gels/ specific products or particular preparations.

DEP System  ensures speed of action, easier regulation of either current delivery and vibration and monitors skin impedance on real time to give users the final results they expect. The new revolutionalry handpiece allows users to see and manage at best the delivery with no waste of product and getting optimal results.

Operators will enjoy the accuracy provided by the DEP System Handpiece for any skin condition and for any length of treatment.

Patients will enjoy treatments with DEP System due to the very high comfortable sessions. Vibration feature  makes electrical pulses delivery perception to decrease significantly and the handpice won’t allow undesired spilling of product.


Easy to use.

FDA cleared as alternative to injections.

Patented proprietary Dermoelectroporation®  Technology.

Non invasive.

Electrical Current perception protected.

Control on homogeneous drug delivery.

Real time skin impedance measurement feature.

Real time transdermal delivery monitoring.

Control on amount of drug

to be delivered and time of treatment.

Capability of Transdermal Delivery of ionic drug solution of macromolecules (greater than 800.000Dalton!!).

Users don’t need to change their existing protocols.

Some applications:

• Hyperhidrosys

• Skin Rejuvenation treatments

• Wrinkles treatments

• Pre laser treatments

• Pre and post plastic surgery sessions

• Skin Whitening treatments

• Steroids applications

• Aesthetic applications

• Replacing injections

• Mesotherapy applications

and many others…

Some deliverable solutions

• Type A Botulinum Toxine

• Phosphatidylcoline

• Hyaluronic Acid

• Aminophylline

• Grow Factors

• Amino Acids

• L-Carnitine

• Lidocaine

• Heparine

• Collagen

• Vitamins

• Steroids

• Elastine

and many others…

Benefit to patients:

  • Astonishing results
  • Comfortable  treatment sessions    
  • No irritations, burnings or inflammations for return electrode placement  
  • No trauma from injections
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